Fixing Dv-1 Cells Inoculated with DiNV For Titering

  • This is 48 hours after inoculation
  • Fresh 80% acetone for fixing had already been made up and stored at -20C
  • Acetone then placed on ice for use
  • Two 48 well plates of inoculated Dv-1 cells were dumped out onto paper towels and tapped down (towels were disposed of in autoclave waste)
  • Slowly dripped with serological pipette the 80% acetone into each well that had cells until each well was full
  • Placed plates in -20 freezer for 30 minutes
  • Tapped and dumped out plates again to remove the acetone
  • Let the plates dry with the lid open for 20 minutes
  • Placed the plates covered in the -20 freezer overnight